The 2019-new coronavirus epidemic: Evidence for virus evolution.
Identifieur interne : 000178 ( Main/Exploration ); précédent : 000177; suivant : 000179The 2019-new coronavirus epidemic: Evidence for virus evolution.
Auteurs : Domenico Benvenuto [Italie] ; Marta Giovanetti [Brésil] ; Alessandra Ciccozzi [Italie] ; Silvia Spoto [Italie] ; Silvia Angeletti [Italie] ; Massimo Ciccozzi [Brésil]Source :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- Animals, Bayes Theorem, Betacoronavirus, Chiroptera, Coronavirus, Coronavirus Infections, Evolution, Molecular, Humans, Phylogeny, SARS Virus.
Abstract
There is a worldwide concern about the new coronavirus 2019-nCoV as a global public health threat. In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic tree has been built using the 15 available whole genome sequences of 2019-nCoV, 12 whole genome sequences of 2019-nCoV, and 12 highly similar whole genome sequences available in gene bank (five from the severe acute respiratory syndrome, two from Middle East respiratory syndrome, and five from bat SARS-like coronavirus). Fast unconstrained Bayesian approximation analysis shows that the nucleocapsid and the spike glycoprotein have some sites under positive pressure, whereas homology modeling revealed some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019-nCoV significantly clustered with bat SARS-like coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in Spike Glycoprotein and nucleocapsid protein. From these results, the new 2019-nCoV is distinct from SARS virus, probably trasmitted from bats after mutation conferring ability to infect humans.
DOI: 10.1002/jmv.25688
PubMed: 31994738
Affiliations:
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In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic tree has been built using the 15 available whole genome sequences of 2019-nCoV, 12 whole genome sequences of 2019-nCoV, and 12 highly similar whole genome sequences available in gene bank (five from the severe acute respiratory syndrome, two from Middle East respiratory syndrome, and five from bat SARS-like coronavirus). Fast unconstrained Bayesian approximation analysis shows that the nucleocapsid and the spike glycoprotein have some sites under positive pressure, whereas homology modeling revealed some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019-nCoV significantly clustered with bat SARS-like coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in Spike Glycoprotein and nucleocapsid protein. From these results, the new 2019-nCoV is distinct from SARS virus, probably trasmitted from bats after mutation conferring ability to infect humans.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>Italie</li></country><region><li>Latium</li><li>État de Rio de Janeiro</li></region><settlement><li>Rio de Janeiro</li><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Benvenuto, Domenico" sort="Benvenuto, Domenico" uniqKey="Benvenuto D" first="Domenico" last="Benvenuto">Domenico Benvenuto</name></region><name sortKey="Angeletti, Silvia" sort="Angeletti, Silvia" uniqKey="Angeletti S" first="Silvia" last="Angeletti">Silvia Angeletti</name><name sortKey="Ciccozzi, Alessandra" sort="Ciccozzi, Alessandra" uniqKey="Ciccozzi A" first="Alessandra" last="Ciccozzi">Alessandra Ciccozzi</name><name sortKey="Spoto, Silvia" sort="Spoto, Silvia" uniqKey="Spoto S" first="Silvia" last="Spoto">Silvia Spoto</name></country><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Giovanetti, Marta" sort="Giovanetti, Marta" uniqKey="Giovanetti M" first="Marta" last="Giovanetti">Marta Giovanetti</name></region><name sortKey="Ciccozzi, Massimo" sort="Ciccozzi, Massimo" uniqKey="Ciccozzi M" first="Massimo" last="Ciccozzi">Massimo Ciccozzi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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